Proposed model of the Dictyostelium cAMP receptors bound to cAMP
نویسندگان
چکیده
منابع مشابه
The cyclic nucleotide specificity of three cAMP receptors in Dictyostelium.
cAMP receptors mediate signal transduction pathways during development in Dictyostelium. A cAMP receptor (cAR1) has been cloned and sequenced (Klein, P., Sun, T. J., Saxe, C. L., Kimmel, A. R., Johnson, R. L., and Devreotes, P. N. (1988) Science 241, 1467-1472) and recently several other cAR genes have been identified (Saxe, C. L., Johnson, R., Devreotes, P. N., and Kimmel, A. R. (1991a) Dev. G...
متن کاملCharacterization of a cAMP-stimulated cAMP phosphodiesterase in Dictyostelium discoideum.
A cyclic nucleotide phosphodiesterase, PdeE, that harbors two cyclic nucleotide binding motifs and a binuclear Zn(2+)-binding domain was characterized in Dictyostelium. In other eukaryotes, the Dictyostelium domain shows greatest homology to the 73-kDa subunit of the pre-mRNA cleavage and polyadenylation specificity factor. The Dictyostelium PdeE gene is expressed at its highest levels during a...
متن کاملTwo cAMP receptors activate common signaling pathways in Dictyostelium.
Multiple signal transduction pathways within a single cell may share common components. In particular, seven different transmembrane helix receptors may activate identical pathways by interacting with the same G-proteins. Dictyostelium cells respond to cAMP using one such receptor, cAR1, coupled by a typical heterotrimeric G-protein to intracellular effectors. However, cells in which the gene f...
متن کاملcAMP waves in Dictyostelium territories
The cover illustration is a stylized image, with a field of view of several millimetres, of cyclic AMP waves in populations of the single-cell microorganism Dictyostelium discoideum on the surface of agar. These waves are ‘target patterns’ driven by pacemaker cells at their centres. Targets compete with rotating spirals during the stage of the life cycle of Dictyostelium in which travelling che...
متن کاملKinetics and concentration dependence of reversible cAMP-induced modification of the surface cAMP receptor in Dictyostelium.
We have previously reported that extracellular cAMP induced a reversible shift, from apparent Mr = 40,000 to 43,000, in the electrophoretic mobility of a polypeptide identified by photoaffinity labeling with [32P]8-N3-cAMP as the cAMP receptor of Dictyostelium (Klein, P., Theibert, A., Fontana, D., and Devreotes, P. (1985) J. Biol. Chem. 260, 1757-1764). In this report, we examine the kinetics ...
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ژورنال
عنوان ژورنال: Journal of Molecular Graphics and Modelling
سال: 2020
ISSN: 1093-3263
DOI: 10.1016/j.jmgm.2020.107662